Brain cancer mortality rates increase with Toxoplasma gondii seroprevalence in France

Infection, Genetics and Evolution
By: , and 

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Abstract

The incidence of adult brain cancer was previously shown to be higher in countries where the parasite Toxoplasma gondii is common, suggesting that this brain protozoan could potentially increase the risk of tumor formation. Using countries as replicates has, however, several potential confounding factors, particularly because detection rates vary with country wealth. Using an independent dataset entirely within France, we further establish the significance of the association between T. gondii and brain cancer and find additional demographic resolution. In adult age classes 55 years and older, regional mortality rates due to brain cancer correlated positively with the local seroprevalence of T. gondii. This effect was particularly strong for men. While this novel evidence of a significant statistical association between T. gondii infection and brain cancer does not demonstrate causation, these results suggest that investigations at the scale of the individual are merited.

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Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Brain cancer mortality rates increase with Toxoplasma gondii seroprevalence in France
Series title Infection, Genetics and Evolution
DOI 10.1016/j.meegid.2012.01.013
Volume 12
Issue 2
Year Published 2012
Language English
Publisher Elsevier
Contributing office(s) Western Ecological Research Center
Description 3 p.
Larger Work Type Article
Larger Work Subtype Journal Article
Larger Work Title Infection, Genetics and Evolution
First page 496
Last page 498
Country France