Efficacy of an extract from garlic, Allium sativum, against infection with the furunculosis bacterium, Aeromonas salmonicida, in rainbow trout, Oncorhynchus mykiss

Journal of the World Aquaculture Society
Kate E. Breyer, Rodman G. Getchell, Emily R. Cornwell, and Gregory A. Wooster (Aquatic Animal Health Program, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853) and H. George Ketola (Tunison Laboratory of Aquatic Science, United States Geological Survey, 3075 Gracie Road, Cortland, NY 13045) and Paul R. Bowser (Aquatic Animal Health Program, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853)
By: , and 

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Abstract

Juvenile rainbow trout, Oncorhynchus mykiss, were fed diets containing 0, 0.5, 1.0, and 2.0% of a garlic extract, challenged with a modified 50% lethal dose of Aeromonas salmonicida and monitored for 28 d. There were significant increases in survival of trout fed 0.5 and 1.0% garlic extract as compared to the control and 2.0% garlic extract groups. A target animal safety study was performed at varying increments using the target dose of 0.5% garlic extract at 0× (0% garlic extract), 1× (0.5% garlic extract), 3× (1.5% garlic extract), and 5× (2.5% garlic extract) for 3× (6 wk) the duration of the original study. There was a significant increase in the level of circulating lymphocytes and a significant decrease in the level of circulating monocytes. The latter correlated to an increased level of pigment-containing macrophage centers within the renal tissue as garlic extract dosing increased, denoting a potential deleterious inflammatory effect as macrophage infiltration became severe at the highest dose. These studies suggest that feeding low-dose (0.5% or 1.0%) garlic extract improves survivability in rainbow trout when challenged with A. salmonicida and appears safe; however, higher levels do not appear to be effective and may cause deleterious effects on health.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Efficacy of an extract from garlic, Allium sativum, against infection with the furunculosis bacterium, Aeromonas salmonicida, in rainbow trout, Oncorhynchus mykiss
Series title Journal of the World Aquaculture Society
DOI 10.1111/jwas.12195
Volume 46
Issue 3
Year Published 2015
Language English
Publisher World Aquaculture Society
Publisher location Baton Rouge, LA
Contributing office(s) Great Lakes Science Center
Description 10 p.
First page 273
Last page 282
Online Only (Y/N) N
Additional Online Files (Y/N) N