Biodegradation of dichlorodiphenyltrichloroethane: Intermediates in dichlorodiphenylacetic acid metabolism by Aerobacter aerogenes
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Abstract
The final product of dichlorodiphenyltrichloroethane (DDT) degradation by vertebrates is commonly considered to be dichlorodiphenylacetic acid, DDA (J. E. Peterson and W. H. Robison, Toxicol. Appl. Pharmacol. 6:321, 1964). Recently, certain organisms (A. S. Perry, S. Miller, and A. J. Buckner. J. Agr. Food Chem. 11:457, 1963; J. D. Pinto, M. N. Comien, and M. S. Dunn. J. Biol. Chem. 240:2148, 1965) have been found to degrade further DDA to dichlorobenzophenone (DBP), but the possibility that such degradation was due to microbial action could not be excluded. Significantly, dichlorobenzhydrol (DBH), dichlorophenylmethane (DPM), and dichlorodiphenylethylene (DDE) have been tentatively identified in rats fed DDA (Pinto et al., J. Biol. Chem. 240:2148, 1965). Since DDA as well as DDT is degraded by the ubiquitous microorganism Aerobacter aerogenes (G. Wedemeyer, Appl. Microbiol. 15:569, 1967; J. L. Mendel, and M. S. Walton, Science 151:1527, 1966), it seemed reasonable that the intestinal microflora might be involved in DBP formation, DPM and DBH being intermediates in its pathway from DDA. Since DDA is a (3,y-unsaturated acid, ketone formation via an alkene and an alcohol would be expected (S. G. Waley, Mechanisms of Organic and Enzymatic Reactions, Oxford University Press, London, England 1962).
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Biodegradation of dichlorodiphenyltrichloroethane: Intermediates in dichlorodiphenylacetic acid metabolism by Aerobacter aerogenes |
| Series title | Applied Microbiology |
| DOI | 10.1128/am.15.6.1494-1495.1967 |
| Volume | 15 |
| Issue | 6 |
| Year Published | 1967 |
| Language | English |
| Publisher | American Society for Microbiology |
| Contributing office(s) | Western Fisheries Research Center |
| Description | 2 p. |
| First page | 1494 |
| Last page | 1495 |
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