Organochlorine insecticide, herbicide and polychlorinated biphenyl (PCB) inhibition of NaK-ATPase in rainbow trout

Bulletin of Environmental Contamination and Toxicology
By: , and 

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Abstract

The current widespread presence of chlorinated insecticides, polychlorinated biphenyls (PCB's) and herbicides in world waterways has elicited much interest in the mechanisms of their toxicity in fishes. Inhibition of Na+,K+-activated adenosinetriphosphatase (NaK-ATPase) and Mg++-dependent ATPase (Mg-ATPase) by DDT, endosulfan and dicofol has been demonstrated in gill, brain and kidney microsomes of rainbow trout (1,2). Intestinal and gill ATPases in marine teleosts were recently reported to be sensitive to organochlorines (3). CutkonTp et al (4) noted inhibition of NaK-ATPase and Mg-ATPase in bluegill brain, liver, muscle and kidney by DDT and related chlorinated hydrocarbons. Inhibition of ATPases by PCB's has been recently shown in bluegill kidney, brain and liver (5). In the present study, we have further examined the NaK-ATPase enzyme system in trout gill as a site for the possible toxicity of selected organopolychlors, i.e., chlorinated insecticides, herbicides and PCB's.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Organochlorine insecticide, herbicide and polychlorinated biphenyl (PCB) inhibition of NaK-ATPase in rainbow trout
Series title Bulletin of Environmental Contamination and Toxicology
DOI 10.1007/BF01684507
Year Published 1972
Language English
Publisher Springer
Contributing office(s) Western Fisheries Research Center
Description 4 p.
First page 69
Last page 72
Online Only (Y/N) N
Additional Online Files (Y/N) N