Neutralizing monoclonal antibodies recognize antigenic variants among isolates of infectious hematopoietic necrosis virus

Diseases of Aquatic Organisms
By: , and 

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Abstract

eutralizing monoclonal antibodies were developed against strains of infectious hematopoietic necrosis virus (IHNV) from steelhead trout Salmo gairdneri in the Deschutes River of Oregon, chinook salmon Oncorhynchus tshawytscha in the Sacramento River of California, and rainbow trout Salmo gairdneri reared in the Hagerman Valley of Idaho, USA. These antibodies were tested for neutralization of 12 IHNV isolates obtained from salmonids in Japan, Alaska, Washington, Oregon, California, and Idaho. The antibodies recognized antigenic variants among the isolates and could be used to separate the viruses into 4 groups. The members of each group tended to be related by geographic area rather than by source host species, virulence, or date of isolation.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Neutralizing monoclonal antibodies recognize antigenic variants among isolates of infectious hematopoietic necrosis virus
Series title Diseases of Aquatic Organisms
Volume 4
Year Published 1988
Language English
Publisher Inter-Research
Contributing office(s) Western Fisheries Research Center
Description 6 p.
First page 199
Last page 204
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