Studies of certain sulfonamide drugs for use in juvenile chinook salmon

Progressive Fish-Culturist
By: , and 

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Abstract

Sulfamethazine, introduced to fishery medicine by Snieszko and Friddle in 1950, has been widely accepted for treatment of systemic bacterial infections of fish. When administered to fish in their diet, this drug is effective against susceptible bacteria but has the disadvantages of being slowly absorbed (Snieszko and Friddle, 1951) and relatively toxic (Wood, Yasutake, and Johnson, 1957). Today there are many sulfonamides which are more efficacious than sulfamethazine. In domestic animals, sulfisoxazole and sulfadimethoine are absorbed quickly from the gastrointestinal tract and have fewer toxic side reactions, a wider antibacterial spectrum, and better bacteriostatic activity.

In the work described in this paper, the efficacies of sulfisoxazole and sulfadimethoxine were compared to the efficacy of sulfamethazine. Experiments were designed to determine the rate of intestinal absorption, the rate of elimination from the blood, the effect on growth, and the toxicity of each drug in juvenile chinook salmon (Oncorhynchus tshawytscha). The comparative bacteriostatic activity against two common fish pathogens was also determined for each drug. 

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Studies of certain sulfonamide drugs for use in juvenile chinook salmon
Series title Progressive Fish-Culturist
DOI 10.1577/1548-8640(1969)31[202:SOCSDF]2.0.CO;2
Volume 31
Issue 4
Year Published 1969
Language English
Publisher American Fisheries Society
Description 5 p.
First page 202
Last page 206
Online Only (Y/N) N
Additional Online Files (Y/N) N