In vivo effects of bisphenol A in laboratory rodent studies

Reproductive Toxicology
By: , and 

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Abstract

Concern is mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical used in synthesis of plastics. We have reviewed the growing literature on effects of low doses of BPA, below 50 mg/(kg day), in laboratory exposures with mammalian model organisms. Many, but not all, effects of BPA are similar to effects seen in response to the model estrogens diethylstilbestrol and ethinylestradiol. For most effects, the potency of BPA is approximately 10–1000-fold less than that of diethylstilbestrol or ethinylestradiol. Based on our review of the literature, a consensus was reached regarding our level of confidence that particular outcomes occur in response to low dose BPA exposure. We are confident that adult exposure to BPA affects the male reproductive tract, and that long lasting, organizational effects in response to developmental exposure to BPA occur in the brain, the male reproductive system, and metabolic processes. We consider it likely, but requiring further confirmation, that adult exposure to BPA affects the brain, the female reproductive system, and the immune system, and that developmental effects occur in the female reproductive system.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title In vivo effects of bisphenol A in laboratory rodent studies
Series title Reproductive Toxicology
DOI 10.1016/j.reprotox.2007.06.004
Volume 24
Issue 2
Year Published 2007
Language English
Publisher Elsevier
Contributing office(s) Columbia Environmental Research Center
Description 26 p.
First page 199
Last page 224
Online Only (Y/N) N
Additional Online Files (Y/N) N