Association mapping of genetic risk factors for chronic wasting disease in wild deer
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Abstract
Chronic wasting disease (CWD) is a fatal transmissible spongiform encephalopathy affecting North American cervids. We assessed the feasibility of association mapping CWD genetic risk factors in wild white-tailed deer (Odocoileus virginianus) and mule deer (Odocoileus hemionus) using a panel of bovine microsatellite markers from three homologous deer linkage groups predicted to contain candidate genes. These markers had a low cross-species amplification rate (27.9%) and showed weak linkage disequilibrium (<1 cM). Markers near the prion protein and the neurofibromin 1 (NF1) genes were suggestively associated with CWD status in white-tailed deer (P = 0.006) and mule deer (P = 0.02), respectively. This is the first time an association between the NF1 region and CWD has been reported.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Association mapping of genetic risk factors for chronic wasting disease in wild deer |
| Series title | Evolutionary Applications |
| DOI | 10.1111/eva.12003 |
| Volume | 6 |
| Issue | 2 |
| Year Published | 2013 |
| Language | English |
| Publisher | Blackwell Publishing Ltd |
| Publisher location | Hoboken, NJ |
| Contributing office(s) | Coop Res Unit Leetown |
| Description | 13 p. |
| First page | 340 |
| Last page | 352 |
| Online Only (Y/N) | N |
| Additional Online Files (Y/N) | N |
| Google Analytic Metrics | Metrics page |