Hepeviruses of fish

Edited by: Frederick S. B. Kibenge and Marcos Godoy



Originally reported from California, the cutthroat trout virus (CTV) has now been isolated from eight species of salmonids in North America. Early work focused on the replication and physical characteristics of the small, round virus, but not until 20 years later was it determined to be most closely related to viruses causing hepatitis E in humans or infecting avian and mammalian hosts. The genome of CTV consists of 7269 nucleotides of positive-sense, single-stranded RNA with a genome organization similar to other members of the family Hepeviridae, although the amino acid sequence identity appears low enough to support creation of a novel genus. While CTV has not been associated with acute disease in fish, the virus was able to form persistently infected cell cultures that may aid research in treatment of hepatitis E-like viruses affecting humans or other animals. Interestingly, trout exposed to CTV were protected for about a month against subsequent exposure to Infectious hematopoietic necrosis virus. Replicating agents suspected to be CTV can be confirmed by polymerase chain reaction (PCR) and sequencing.

Publication type Book chapter
Publication Subtype Book Chapter
Title Hepeviruses of fish
Chapter 24
DOI 10.1016/B978-0-12-801573-5.00024-3
Year Published 2016
Language English
Publisher Elsevier
Contributing office(s) Western Fisheries Research Center
Description 5 p.
Larger Work Type Book
Larger Work Subtype Monograph
Larger Work Title Aquaculture virology
First page 365
Last page 369
Online Only (Y/N) N
Additional Online Files (Y/N) N
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