Biomagnification of bioassay derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents

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In recent years contamination of the Great Lakes ecosystem with planar chlorinated hydrocarbons (PCHs) has attracted considerable concern due to their known reproductive and teratogenic effects. The H4IIE bioassay has been standardized as a means of measuring the biological potency of a PCH mixture as 2,3,7,8-tetrachloro-p-dibenzodioxin equivalents (TCDD-EQ). Using this bioassay we have investigated the biomagnification of TCDD-EQ in a semi-closed ecosystem. The biomagnification of TCDD-EQ is demonstrated and results indicate that the food chain is the major pathway for TCDD-EQ through this ecosystem. The H4IIE assay system is demonstrated to be a viable integrative measure of the total concentration of TCDD-EQ in different trophic levels.

Publication type Article
Publication Subtype Journal Article
Title Biomagnification of bioassay derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents
Series title Chemosphere
DOI 10.1016/0045-6535(93)90206-K
Volume 26
Issue 6
Year Published 1993
Language English
Publisher Elsevier
Contributing office(s) Columbia Environmental Research Center
Description 10 p.
First page 1203
Last page 1212
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