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Involvement of rainbow trout leucocytes in the pathogenesis of infectious hematopoietic necrosis

Diseases of Aquatic Organisms
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Abstract

Rainbow trout Oncorhynchus myluss leucocytes were tested for their ability to support replication of infectious hematopoietic necrosis virus (IHNV). Viral replication occurred in vitro uslng leucocytes cultured from peripheral blood, kidney, and thymus where viral titers peaked at 2 to 4 d post-inoculation. Leucocytes collected from trout following waterborne challenge with IHNV were cocultured on EPC cell monolayers. These assays detected IHNV in leucocytes infected in vivo as early as 6 h post-exposure before the challenge virus had undergone replication. These data showed that leucocyte populations could serve as target cells in the initial phase of IHNV infection.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Involvement of rainbow trout leucocytes in the pathogenesis of infectious hematopoietic necrosis
Series title Diseases of Aquatic Organisms
Year Published 1994
Language English
Publisher Inter-Research
Contributing office(s) Western Fisheries Research Center
Description 6 p.
First page 89
Last page 94
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