Involvement of rainbow trout leucocytes in the pathogenesis of infectious hematopoietic necrosis
Diseases of Aquatic Organisms
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Abstract
Rainbow trout Oncorhynchus myluss leucocytes were tested for their ability to support replication of infectious hematopoietic necrosis virus (IHNV). Viral replication occurred in vitro uslng leucocytes cultured from peripheral blood, kidney, and thymus where viral titers peaked at 2 to 4 d post-inoculation. Leucocytes collected from trout following waterborne challenge with IHNV were cocultured on EPC cell monolayers. These assays detected IHNV in leucocytes infected in vivo as early as 6 h post-exposure before the challenge virus had undergone replication. These data showed that leucocyte populations could serve as target cells in the initial phase of IHNV infection.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Involvement of rainbow trout leucocytes in the pathogenesis of infectious hematopoietic necrosis |
| Series title | Diseases of Aquatic Organisms |
| DOI | 10.3354/DAO019089 |
| Year Published | 1994 |
| Language | English |
| Publisher | Inter-Research |
| Contributing office(s) | Western Fisheries Research Center |
| Description | 6 p. |
| First page | 89 |
| Last page | 94 |
| Google Analytic Metrics | Metrics page |