Novel picornavirus associated with avian keratin disorder in Alaskan birds

mBio
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Abstract

Avian keratin disorder (AKD), characterized by debilitating overgrowth of the avian beak, was first documented in black-capped chickadees (Poecile atricapillus) in Alaska. Subsequently, similar deformities have appeared in numerous species across continents. Despite the widespread distribution of this emerging pathology, the cause of AKD remains elusive. As a result, it is unknown whether suspected cases of AKD in the afflicted species are causally linked, and the impacts of this pathology at the population and community levels are difficult to evaluate. We applied unbiased, metagenomic next-generation sequencing to search for candidate pathogens in birds affected with AKD. We identified and sequenced the complete coding region of a novel picornavirus, which we are calling poecivirus. Subsequent screening of 19 AKD-affected black-capped chickadees and 9 control individuals for the presence of poecivirus revealed that 19/19 (100%) AKD-affected individuals were positive, while only 2/9 (22%) control individuals were infected with poecivirus. Two northwestern crows (Corvus caurinus) and two red-breasted nuthatches (Sitta canadensis) with AKD-consistent pathology also tested positive for poecivirus. We suggest that poecivirus is a candidate etiological agent of AKD.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Novel picornavirus associated with avian keratin disorder in Alaskan birds
Series title mBio
DOI 10.1128/mBio.00874-16
Volume 7
Issue 4
Year Published 2016
Language English
Publisher American Society for Microbiology
Contributing office(s) Alaska Science Center Biology WTEB
Description e00874-16; 10 p.
First page 1
Last page 10