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Immune response to synthetic peptides representing antigenic sites on the glycoprotein of infectious hematopoietic necrosis virus

Veterinary Research
By: , and 

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Abstract

Summary ― Monoclonal antibodies against infectious hematopoietic necrosis virus have been used to react with recombinant expression products in immunoblots and to select neutralization-resistant mutants for sequence analysis. These strategies identified neutralizing and non-neutralizing antigenic sites on the viral glycoprotein. Synthetic peptides based upon the amino acid sequences of these antigenic sites were synthesized and were injected together with an adjuvant into rainbow trout. The constructs generally failed to stimulate neutralizing antibodies in the fish. These results indicate that we need to understand more about the ability of peptide antigens to stimulate fish immune systems.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Immune response to synthetic peptides representing antigenic sites on the glycoprotein of infectious hematopoietic necrosis virus
Series title Veterinary Research
Volume 4 p.
Year Published 1995
Language English
Contributing office(s) Western Fisheries Research Center
First page 374
Last page 378