Wildfire is increasingly a concern in the USA, where 10 million acres burned in 2015. Climate is a primary driver of wildfire, and understanding fire-climate relationships is crucial for informing fire management and modeling the effects of climate change on fire. In the southwestern USA, fire-climate relationships have been informed by tree-ring data that extend centuries prior to the onset of fire exclusion in the late 1800s. Variability in cool-season precipitation has been linked to fire occurrence, but the effects of the summer North American monsoon on fire are less understood, as are the effects of climate on fire seasonality. We use a new set of reconstructions for cool-season (October–April) and monsoon-season (July–August) moisture conditions along with a large new fire scar dataset to examine relationships between multi-seasonal climate variability, fire extent, and fire seasonality in the Jemez Mountains, New Mexico (1599–1899 CE). Results suggest that large fires burning in all seasons are strongly influenced by the current year cool-season moisture, but fires burning mid-summer to fall are also influenced by monsoon moisture. Wet conditions several years prior to the fire year during the cool season, and to a lesser extent during the monsoon season, are also important for spring through late-summer fires. Persistent cool-season drought longer than 3 years may inhibit fires due to the lack of moisture to replenish surface fuels. This suggests that fuels may become increasingly limiting for fire occurrence in semi-arid regions that are projected to become drier with climate change.