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An examination of the effect of aerosolized permanone insecticide on zebra finch susceptibility to West Nile virus

Environmental Toxicology and Chemistry

By:
, , and
https://doi.org/10.1002/etc.3918

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Abstract

West Nile virus is primarily maintained cryptically primarily in avian (Passerine) populations where it is transmitted by Culex spp. mosquitoes. Mosquito control measures currently include physical activities to reduce mosquito breeding sites, the application of mosquito larvicides, or aerosolized insecticides to kill adults (adulticides) when arboviral diseases such as West Nile virus (WNV) or Zika virus are detected in mosquito populations. Organochlorine, organohosphorus, carbamate and pyrethroid insecticides are often used. Previous work suggests an effect of pyrethroids on the immune system in a variety of vertebrates. We examined the effects of exposure to aerosolized Permanone® 30:30 insecticide (permethrin and piperonyl butoxide in soy oil vehicle) at ∼103−106x potential environmental concentrations on the response of captive zebra finches (Taeniopygia guttata) to experimental challenge with WNV. Compared to vehicle control birds, WNV outcome was unchanged (65% of birds produced a viremia) in the ‘low’ exposure (9.52 mg/m3±3.13 SD permethrin) group, but reduced in the ‘high’ exposure (mean 376.5 mg/m3±27.9 SD permethrin) group (30% were viremic) (p < 0.05). After clearing WNV infection, birds treated with Permanone regained less body mass than vehicle treated birds (p < 0.001). Our study suggests that exposure to aerosolized Permanone insecticide at levels exceeding typical application rates has the potential to not change or mildly enhance a bird's resistance to WNV.

Additional publication details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
An examination of the effect of aerosolized permanone insecticide on zebra finch susceptibility to West Nile virus
Series title:
Environmental Toxicology and Chemistry
DOI:
10.1002/etc.3918
Edition:
Online First
Year Published:
2017
Language:
English
Publisher:
Society of Environmental Toxicology and Chemistry
Contributing office(s):
National Wildlife Health Center