The Navajo Nation is an ecologically sensitive semi-arid to arid section of the southern Colorado Plateau. In this remote part of the United States, located at the Four Corners (Arizona, New Mexico, Colorado, and Utah), traditional people live a subsistence lifestyle that is inextricably tied to, and dependent upon, landscape conditions and water supplies. Soft bedrock lithologies and sand dunes dominate the region, making it highly sensitive to fluctuations in precipitation intensity, percent vegetation cover, and local land use practices. However, this region has sparse and discontinuous meteorological monitoring records. As a complement to the scant long-term meteorological records and historical documentation, we conducted interviews with 50 Native American elders from the Navajo Nation and compiled their lifetime observations on the changes in water availability, weather, and sand or dust storms. We then used these observations to further refine our understanding of the historical trends and impacts of climate change and drought for the region. In addition to altered landscape conditions due to climatic change, drought, and varying land use practices over the last 130 years, the Navajo people have been affected by federal policies and harsh economic conditions which weaken their cultural fabric. We conclude that a long-term drying trend and decreasing snowpack, superimposed on regional drought cycles, will magnify drought impacts on the Navajo Nation and leave its people increasingly vulnerable.