Windows of susceptibility and consequences of early life exposures to 17β–estradiol on medaka (Oryzias latipes) reproductive success

Environmental Science & Technology
By: , and 

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Abstract

Estrogens and estrogen mimics are commonly found in surface waters and are associated with deleterious effects in fish populations. Impaired fertility and fecundity in fish following chronic exposures to estrogens and estrogen mimics during critical windows in development are well documented. However, information regarding differential reproductive effects of exposure within defined developmental stages remains sparse. In this study, reproductive capacity was assessed in Japanese medaka (Oryzias latipes) after exposure to two concentrations of 17β–estradiol (E2β; 2 ng/L and 50 ng/L) during four distinct stages of development: gonad development, gonad differentiation, development of secondary sex characteristics (SSC) and gametogenesis. Exposure to E2β did not adversely impact survival, hatch success, growth, or genotypic ratios. In contrast, exposure to 50 ng/L E2β during SSC development altered phenotypic ratios and SSC. Exposure to both E2β treatments reduced reproductive capacity (fertility, fecundity) by 7.3–57.4% in adult medaka breeding pairs, with hindrance of SSC development resulting in the largest disruption in breeding capacity (51.6–57.4% decrease) in the high concentration. This study documents differential effects among four critical stages of development and provides insight into factors (window of exposure, exposure concentration and duration of exposure period) contributing to reproductive disruption in fish.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Windows of susceptibility and consequences of early life exposures to 17β–estradiol on medaka (Oryzias latipes) reproductive success
Series title Environmental Science & Technology
DOI 10.1021/acs.est.7b01568
Volume 51
Issue 9
Year Published 2017
Language English
Publisher ACS Publications
Contributing office(s) Coop Res Unit Atlanta
Description 10 p.
First page 5296
Last page 5305