The Everglades Invasive Reptile and Amphibian Monitoring Program (EIRAMP) provides a scientific framework for integrated EDRR, outreach, and monitoring for invasive wildlife in South Florida. EIRAMP also monitors native reptiles, amphibians and mammals to assess impacts of invasive species. South Florida has more nonnative species of reptiles and amphibians than anywhere else in the world. Some of these species become invasive and harm the environment, economy, and/or public health. Many are predators that can severely impact native species and ecosystems. Controlling and monitoring these invaders are essential to the success of multi-billion dollar Everglades restoration efforts. Prevention and eradication are the most cost-effective ways to limit impacts of invasive species (see Figure 1). Once populations are widely established, management becomes expensive, long-term, and often ineffective. Early detection and rapid response (EDRR) offers the best chance to get ahead of the invasion curve and successfully contain or eradicate populations while they are still localized.