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Ancient convergent losses of Paraoxonase 1 yield potential risks for modern marine mammals

Science

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https://doi.org/10.1126/science.aap7714

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Abstract

Mammals diversified by colonizing drastically different environments, with each transition yielding numerous molecular changes, including losses of protein function. Though not initially deleterious, these losses could subsequently carry deleterious pleiotropic consequences. We have used phylogenetic methods to identify convergent functional losses across independent marine mammal lineages. In one extreme case, Paraoxonase 1 (PON1) accrued lesions in all marine lineages, while remaining intact in all terrestrial mammals. These lesions coincide with PON1 enzymatic activity loss in marine species’ blood plasma. This convergent loss is likely explained by parallel shifts in marine ancestors’ lipid metabolism and/or bloodstream oxidative environment affecting PON1’s role in fatty acid oxidation. PON1 loss also eliminates marine mammals’ main defense against neurotoxicity from specific man-made organophosphorus compounds, implying potential risks in modern environments.

Additional publication details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Ancient convergent losses of Paraoxonase 1 yield potential risks for modern marine mammals
Series title:
Science
DOI:
10.1126/science.aap7714
Volume:
361
Issue:
6402
Year Published:
2018
Language:
English
Publisher:
American Association for the Advancement of Science
Contributing office(s):
Wetland and Aquatic Research Center
Description:
4 p.
First page:
591
Last page:
594