Sedimentary provenance studies have come to be overwhelmingly based upon U–Pb geochronologic measurements performed with detrital zircon while alternative and potentially complementary approaches such as conglomerate clast studies and heavy mineral analysis have faded in importance. Measurement of Pb isotopic compositions in detrital K-feldspar is among the under-utilized approaches available to ascertain sedimentary source regions. While it has been long recognized that common Pb isotope compositions recorded by K-feldspar vary widely and reflect the crustal provinces from which the host basement rocks crystallized, use of the approach has suffered due to a lack of appropriate statistical models and ground truth compositional data from source regions. In this paper, we: (1) present high-throughput LA-ICPMS analysis protocols needed to generate statistically meaningful detrital K-feldspar Pb isotope data sets; (2) develop an interpretative approach based upon ²⁰⁸Pb/²⁰⁶Pb vs. ²⁰⁷Pb/²⁰⁶Pb that incorporate information from the U- and Th-decay systems into one two-dimensional plot that is amenable to analysis using two-dimensional Kolmogorov–Smirnoff statistical tests; (3) generate new Pb isotopic data from basement rocks from southwestern North America to improve knowledge of the Pb isotopic properties of potential source regions; and (4) generate new Pb isotopic data from Lower Eocene to Lower Miocene sedimentary rocks to evaluate changes in drainage patterns that occurred in response to deformation that affected the southern California margin. Through this case study, we demonstrate how our new analytical and interpretative methods could be profitably applied to future geochemical and provenance studies and tectonically driven re-organization of drainage patterns.