Wave-induced flooding is a major coastal hazard on tropical islands fronted by coral reefs. The variability of shape, size, and physical characteristics of the reefs across the globe make it difficult to obtain a parameterization of wave run-up, which is needed for risk assessments. Therefore, we developed the HyCReWW metamodel to predict wave run-up under a wide range of reef morphometric and offshore forcing characteristics. Due to the complexity and high dimensionality of the problem, we assumed an idealized one-dimensional reef profile, characterized by seven primary parameters. XBeach Non-Hydrostatic was chosen to create the synthetic dataset, and Radial Basis Functions implemented in MATLAB® were chosen for interpolation. Results demonstrate the applicability of the metamodel to obtain fast and accurate results of wave run-up for a large range of intrinsic reef morphologic and extrinsic hydrodynamic forcing parameters, offering a useful tool for risk management and early warning systems.