Confronting models with data: The challenges of estimating disease spillover

Philosophical Transactions of the Royal Society B: Biological Sciences
By: , and 

Links

Abstract

For pathogens known to transmit across host species, strategic investment in disease control requires knowledge about where and when spillover transmission is likely. One approach to estimating spillover is to directly correlate observed spillover events with covariates. An alternative is to mechanistically combine information on host density, distribution, and pathogen prevalence to predict where and when spillover events are expected to occur. We use several case studies at the wildlife-livestock disease interface to highlight the challenges, and potential solutions, to estimating spatio-temporal variation in spillover risk. Datasets on multiple host species often do not align in space, time or resolution, and may have no estimates of observation error. Linking these datasets requires they be related to a common spatial and temporal resolution and appropriately propagating errors in predictions can be difficult. Hierarchical models are one potential solution, but for fine-resolution predictions at broad spatial scales many models become computationally challenging. Despite these limitations, the confrontation of mechanistic predictions with observed events is an important avenue for developing a better understanding of pathogen spillover. Systems where data have been collected at all levels in the spillover process are rare, or non-existent, and require investment and sustained effort across disciplines.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Confronting models with data: The challenges of estimating disease spillover
Series title Philosophical Transactions of the Royal Society B: Biological Sciences
DOI 10.1098/rstb.2018.0435
Volume 374
Issue 1782
Year Published 2019
Language English
Publisher The Royal Society
Contributing office(s) Northern Rocky Mountain Science Center, Alaska Science Center, Alaska Science Center Biology WTEB, Patuxent Wildlife Research Center
Description 20180435