The Great Lakes Fishery Commission (GLFC) was created in 1955 to develop a program of eradication or management of sea lamprey populations in the Great Lakes for the protection of the Great Lakes fishery. Beginning in the 1980s the GLFC shifted to an integrated pest management (IPM) model seeking to deploy control measures which target multiple life stages. Currently control efforts focus on limiting the area of infestation using barriers to migratory adults and eradication of larvae from streams using a selective lampricide. The GLFC continues to support multiple research initiatives to develop addition control, improve current control measures, and further advance sea lamprey control. During the past six decades sea lamprey control in the Great Lakes has evolved as the research program has identified technological advances, yet description of this program evolution is scattered among grey literature and technical reports, which are often inaccessible to the outside research community. This review describes how the use of barriers and traps have changed during the history of sea lamprey control, status of these tools within the current program, and outstanding questions that need to be addressed to continue advancing sea lamprey control in the Great Lakes.