⁴⁰Ar/ ³⁹Ar dating results of 133 samples from 84 late Cenozoic volcanic rocks provide emplacement ages that constrain the timing of evaporite collapse and the incision rates of the Colorado River. Our samples are from areas in west-central Colorado, both within and outside of the Carbondale and Eagle collapse centers. Significant pulses of volcanic activity occurred in the intervals from 24 to 22, 16 to 13, 11 to 9, and 8 to 7 Ma. In addition, small flows, widely spaced in time and space were emplaced during the last 4 m.y. Although individual basaltic flows appear to be chemically and isotopically homogeneous, there are significant geochemical and isotopic differences between flows, even between some flows that apparently have the same age within the limits of analytical precision. A low-relief early to middle Miocene erosional surface has been postulated in west-central Colorado. Our studies are consistent with the existence of a low-relief paleotopographic surface that is now at a minimum elevation range of ~2.9–3.4 km outside areas of collapse. Elevation departures from this range suggest that 1000 m of subsidence due to evaporite removal has locally occurred in the Carbondale and Eagle collapse centers. ⁴⁰Ar/ ³⁹Ar ages from downdropped and disrupted basaltic flows in the Carbondale center constrain initial collapse to >13 Ma, the timing of much of the evaporite-related collapse to the past 10–8 m.y., and an increase in the rate of collapse during the last 3 m.y. Ages and elevations of basaltic rocks above the Colorado River in Glenwood Canyon are used to calculate average apparent incision rates for the Colorado River in Glenwood Canyon of 24 mm/k.y. from 7.8 to 3.0 Ma. The average apparent incision rate increased by an order of magnitude to 242 mm/k.y. during the last 3 m.y