Land subsidence associated with groundwater-level declines is stipulated as an “undesirable effect” in California’s Sustainable Groundwater Management Act (SGMA), and has been identified as a potential issue in San Diego, California, USA. The United States Geological Survey (USGS), the Sweetwater Authority, and the City of San Diego, undertook a cooperative study to better understand the hydromechanical response of the coastal aquifer system using Interferometric Synthetic Aperture Radar (InSAR) techniques. Three periods of interest were analyzed for this study that correspond to the periods before and after two substantial changes were made to the location and volume of pumpage: (1) April–August 2016 when groundwater levels and land surface elevation were relatively stable during normal pumping, (2) September 2016–May 2017 when groundwater levels recovered and the land surface uplifted during a period of substantially reduced pumping, (3) June 2017–October 2018 when groundwater levels declined and land subsidence occurred when pumpage resumed and expanded to new wells. Spatial and temporal characterization of the hydromechanical response to changes in pumpage is important for managing land subsidence. Further study using InSAR techniques, especially when combined with ground-based geodetic and monitoring-well networks, will provide water managers information to help effectively manage groundwater resources as stipulated in the SGMA.