We analyze multimethod shear (SH)‐wave velocity (⁠V_S) site characterization data acquired at three permanent and 25 temporary seismograph stations in Oklahoma that recorded M 4+ earthquakes within a 50 km hypocentral distance of at least one of the 2016 M 5.1 Fairview, M 5.8 Pawnee, or M 5.0 Cushing earthquakes to better constrain earthquake ground‐motion modeling in the region. We acquired active‐source seismic data for time‐averaged V_S to 30 m depth (V_S30) at 28 seismograph stations near the Fairview, Pawnee, and Cushing epicentral areas. The SH‐wave refraction travel times coupled with Rayleigh‐ and Love‐wave phase velocity dispersion were extracted and modeled in a nonlinear least‐squares (L2) joint inversion to obtain a best‐fit 1D V_S versus depth profile for each site. At a subset of sites where the preferred L2 inverse model did not optimally fit each of the Love, Rayleigh, and SH travel‐time datasets, we explore application of simulated annealing in a joint inversion to find a more global solution. V_S30 values range from 262 to 807  m/s for the preferred measured (in situ) V_S profiles, or National Earthquake Hazards Reduction Program (NEHRP) site class D to B, and are broadly comparable with estimates from previous data reports in the region. Site amplification estimates were calculated next from 1D SH transfer functions of the preferred VSVS profiles and then compared against observed horizontal‐to‐vertical spectral ratios (HVSRs) from nearby seismograph stations. We generally see good agreement between the predicted in situ model and the observed HVSR resonant frequencies, with nominal amplifications between 2 and 10 within the 2–15 Hz frequency band. Next, using 40 known in situ V_S30 measurements in the region, we demonstrate that the in situ V_S30 values improve the fit for selected suites of ground‐motion models (GMMs) for M 4+ earthquakes within a 50 km hypocentral distance when compared with proxy methods, arguing for future development of GMMs implementing in situ V_S profiles.