The Sky Island Restoration Collaborative (SIRC) is a growing partnership between government agencies, nonprofit organizations, and private landowners in southeast Arizona, the United States, and northern Sonora, Mexico. Starting in 2014 as an experiment to cultivate restoration efforts by connecting people across vocations and nations, SIRC has evolved over 5 years into a flourishing landscape-restoration initiative. The group is founded on the concept of developing a restoration economy, where ecological and socioeconomic benefits are interconnected and complimentary. The variety of ideas, people, field sites, administration, and organizations promote learning and increase project success through iterative adaptive management, transparency, and sharing. The collaborative seeks to make restoration self-sustaining and improve quality of life for citizens living along the US-Mexico border. Research and experiments are developed between scientists and practitioners to test hypotheses, qualify procedures, and quantify impacts on shared projects. Simultaneously, partners encourage and facilitate connecting more people to the landscape—via volunteerism, internships, training, and mentoring. Through this history, SIRC’s evolution is pioneering the integration of community and ecological restoration to protect biodiversity in the Madrean Archipelago Ecoregion. This editorial introduces SIRC as a unique opportunity for scientists and practitioners looking to engage in binational partnerships and segues into this special journal issue we have assembled that relates new findings in the field of restoration ecology.