Analyses of lead isotopes in galena in carbonate rock ore deposits collected from several mineralized districts in the Central and Eastern Interior of the United States support previous studies in establishing that the galena is anomalously radiogenic ("J"type")- This study, using care-fully selected samples to test some géologie relationships, shows region-wide and distrietwide systematic variations in isotope ratios. The genetic implications of thèse variations are discussed. Two mechanisms of origin are considered to explain thèse variations in isotopic ratios. One involves mixing of leads from multiple sources, the other calls for variable lead-isotope ratios originating from a single source. Several source materials for the lead ores have been suggested; whether a single source has predominated, or two or more main sources have predominated is still unresolved. Slopes from Pb206/Pb204 versus Pb207/Pb204 plot are compatible with a contribution of lead by the 1300 ± 300 m.y. basement rocks that underlie the deposits. The spatial relationships of alkaline igneous rocks to several of the minerai districts in the Mississippi Valley région suggest a possible mag-matic source for the lead. Isotopic analyses of galenas closely associated with several of the intrusive rocks are similar in isotopic composition to adjacent ore leads, but genetic implications are ambiguous. Galena oc-curring in shales in the Mississippi Valley région outside mineralized districts contains ordinary lead. Théories that call upon such shales to be the major source of the lead in the depoaits of the Mississippi Valley type must explain this distinct différence in isotopic compositions. Galena collected from districts within the Appalachian Ridge and Valley Province contains notably less radiogenic lead than that from the Mississippi Valley minerai districts, and the lead is of the ordinary type.