The management of shared resources in the United States–Mexican border region requires cooperation from the people of both countries to assess and understand their relation to the environment. Society is dependent on the long-term healthy functioning of ecosystems and their ability to supply food and raw materials. Likewise, resources and services obtained from nature could be used efficiently within the society. A more equitable distribution of costs and benefits related to goods and services can lead to fewer tensions and a higher quality of life for all the people in the Borderlands. Urban development, background contamination from mineral ore deposits, irrigation, sewage effluent, and even global climate change all have the potential to alter the stability of the fragile systems in the Borderlands (Brady and others, 2001, 2002; Norman, 2007, 2010; Gu and others, 2008; Norman, Gray, and others, 2008; Norman, Hirsch, and Ward, 2008; Norman, Callegary, and others, 2010; Norman, Huth, and others, 2010; Norman, Levick, and others, 2010; Norman, Tallent-Halsell, and others, 2010; Norman, Villarreal, and others 2012). Social efficiency means that because resources should be used where they are needed most, they should be distributed proportionally among human societies and individuals (Azar and others, 1996). Despite the critical role natural resources play in maintaining human and environmental health, current knowledge of the manner in which natural and human-caused forces interact to limit these resources—including their quality and quantity (such as through spatiotemporal changes in precipitation, evapotranspiration, pumping of groundwater, and release of contaminants)—is inadequate. The U.S. Geological Survey (USGS) is trying to understand the relation between changing landscapes, changing demographics, and a changing climate in the Borderlands while the environmental, economic, and societal issues continue to be intertwined between the two nations.