As a part of a 9-year (1999-2007) study done by the U.S. Geological Survey in cooperation with the San Antonio Water System to improve understanding of the San Antonio segment of the Edwards aquifer, south-central Texas, in and near the freshwater/saline-water transition zone of the aquifer, the U.S. Geological Survey collected water-level, borehole geophysical, and water-quality data during 1999-2007 from 37 wells arranged in nine transects (except for two wells) across the freshwater/saline-water interface of the aquifer. This report presents the data collected and also describes the data-collection, analytical, and quality-assurance methods used. The wells, constructed with casing from land surface into the upper part of the aquifer and completed as open hole in the aquifer, are in Uvalde County (East Uvalde transect), in Medina County (South Medina and Devine wells), in Bexar County (Pitluk, Mission, and San Antonio transects), in Comal and Guadalupe Counties (Tri-County transect), in Comal County (New Braunfels transect), and in Hays County (Fish Hatchery, San Marcos, and Kyle transects). Data collected included continuous water level at 18 wells; fluid electrical conductivity and temperature with depth (fluid profiles) obtained by borehole geophysical logging of 15 wells; discrete (periodic) samples for major ions and trace elements at 36 wells; stable isotopes or stable isotopes and tritium at 27 wells; dissolved gases obtained by pumping (or collecting flow) of 19 wells; and continuous specific conductance and temperature at three of the wells equipped with continuous water-level sensors.