The Mojave River and the associated aquifer system are important water supplies in the Mojave Desert of southern California. The river and aquifer system are in hydraulic connection in many areas, and when flow conditions change in one, the other usually is affected. The river is an unpredictable source of water; therefore, residents of the basin rely almost entirely on ground water for their water supply. This reliance on ground water has resulted in overdraft conditions that have caused water-level declines, changes in the quantity and spatial distribution of recharge from the Mojave River, and loss of riparian habitat. The U.S. Geological Survey (USGS), in cooperation with the Mojave Water Agency (MWA), has completed several studies to determine the likely effects of overdraft on the ground-water and surface-water relations along the Mojave River. This report summarizes those studies, highlighting some of the simulation results from a ground-water flow model, and describes the ground-water and surface-water conditions of the Mojave River Basin.