The Tintina gold province is an arc-shaped 2,000-kilometer-long metallogenic province that extends from northern British Columbia, through the Yukon Territory, and across and into southwestern Alaska. In the United States, the province remains a prime area for gold exploration and includes such large gold deposits as Pogo, Fort Knox-True North, and Donlin Creek. In recent years, gold exploration and development and mining activity have accelerated in the area. Plans have been discussed for public and private projects and infrastructures associated with development. A U.S. Geological Survey study undertaken from 2002 to 2007 provides a context for understanding why and how the mineral resources of the area were formed, why this area is so abundantly endowed, and how the environmental signatures that are characteristic of the area are related to the development of mineral resources. Characterization of natural baseline metal concentrations in the area's watersheds is necessary to address future land-use issues related to mining and/or infrastructure activities. A thorough understanding of water-rock and element-bioavailability processes will help predict the possible environmental impact of development. The five tasks of this study add to the science of defining and understanding an 'intrusion-related gold system.'