Changes to the Earth's climate-temperature, precipitation, and other important aspects of climate-pose significant challenges to our Nation's natural resources now and will continue to do so. Managers of land, water, and living resources need to understand the impacts of climate change-which will exacerbate ongoing stresses such as habitat fragmentation and invasive species-so they can design effective response strategies. In 2008 Congress created the National Climate Change and Wildlife Science Center (NCCWSC) within the U.S. Geological Survey (USGS); this center was formed to address challenges resulting from climate change and to empower natural resource managers with rigorous scientific information and effective tools for decision-making. Located at the USGS National Headquarters in Reston, Virginia, the NCCWSC has invested over $20M in cutting-edge climate change research and is now leading the effort to establish eight regional Department of the Interior (DOI) Climate Science Centers (CSCs).