The U.S. Geological Survey, in partnership with The Nature Conservancy, analyzed existing water-quality and streamflow data from three locations in the Upper White River Basin, Indiana, to estimate annual mean concentrations and fluxes and to identify and quantify changes in water quality and streamflow over time. Water-quality data used in the analyses were collected between water years 1992 and 2017. Annual mean-daily concentrations and fluxes of total suspended solids, total phosphorus as phosphorus, nitrate plus nitrite as nitrogen, and total Kjeldahl nitrogen as nitrogen were estimated for U.S. Geological Survey streamgage locations in Indiana on the Upper White River at Muncie, near Nora, and near Centerton. In addition, flow-normalized annual mean-daily concentrations and fluxes of total suspended solids, total phosphorus, nitrate plus nitrite, and total Kjeldahl nitrogen were estimated and used to assess changes in these constituents between water years 1997 and 2017. Flow normalization is a process that attempts to remove the effects of year-to-year variation in streamflow on concentrations and fluxes without removing the effects associated with seasonal and long-term (multiyear) trends in streamflow.