This handbook provides information to residents of the Central United States about the threat of earthquakes in that area, particularly along the New Madrid seismic zone, and explains how to prepare for, survive, and recover from such events. It explains the need for concern about earthquakes for those residents and describes what one can expect during and after an earthquake. Much is known about the threat of earthquakes in the Central United States, including where they are likely to occur and what can be done to reduce losses from future earthquakes, but not enough has been done to prepare for future earthquakes. The handbook describes such preparations that can be taken by individual residents before an earthquake to be safe and protect property.