Increasing demands on the Colorado River system within the arid Southwestern United States have focused attention on finding new, alternative sources of water. Particular attention is being paid to the eastern Great Basin, where important ground-water systems occur within a regionally extensive sequence of Paleozoic carbonate rocks and in the Cenozoic basin-fill deposits that occur throughout the region. Geophysical investigations to characterize the geologic framework of aquifers in eastern Nevada and western Utah began in a series of cooperative agreements between the U.S. Geological Survey and the Southern Nevada Water Authority in 2003. These studies were intended to better understand the formation of basins, define their subsurface shape and depth, and delineate structures that may impede or enhance groundwater flow. We have combined data from gravity stations established during the current study with previously available data to produce an up-to-date isostatic-gravity map of the study area, using a gravity inversion method to calculate depths to pre-Cenozoic basement rock and to estimate alluvial/volcanic fill in the valleys.