The Regional Aquifer-System Analysis Program of the U.S. Geological Survey began in 1978. The overall purpose of this program is to define the geologic, hydrologic, and geochemical framework of the Nation's most important aquifers and aquifer systems. This report summarizes the aquifer or aquifer system name, geographic area, rock units, equivalent names, lithology, thickness, hydrologic characteristics, water quality, water use, and references for 157 aquifers in 23 areas of the United States. A .zip file containing the aquifer data and data search programs (in compressed ASCII format) is included in the report.