More than 700 water samples were collected from 232 wells and 34 surface-water sites in the Santa Clara-Calleguas Hydrologic Unit, Ventura County, California, from October 1989 through December 1993 as part of the U.S. Geological Survey's Southern California Regional Aquifer-System Analysis study. Most samples were analyzed for major ions, nutrients, selected trace elements, oxygen-18, and deuterium. Selected samples were analyzed for one or more of the following isotopes: carbon-13/12, carbon-14, strontium-87/86, sulfur-34/32, and tritium. Other samples were analyzed for one or more of the following dissolved gases: hydrogen, methane, oxygen, and freon-11. Location of sampling sites is shown on maps and the results are presented in tables.