During 2011, excessive precipitation resulted in widespread flooding in the Central United States with 33 fatalities and approximately $4.2 billion in damages reported in the Souris/Red River of the North (Souris/Red) and Mississippi River Basins. At different times, beginning in late February 2011 and extending through September 2011, various rivers in these basins had major flooding, with some locations receiving multiple rounds of flooding. Peak streamflow records were broken at 105 streamgages in the Souris/Red and Mississippi River Basins and annual runoff volume records set at 47 of the 211 streamgages analyzed for annual runoff. For the period of 1950 through 2011, the Ohio River provided almost one-half of the annual runoff at Vicksburg; the Missouri River contributed less than one-fourth, and the lower Mississippi River less than one-fourth. Those relative contribution patterns also occurred in 1973 and 2011, with the notable exception of the decrease in contribution of the lower Mississippi River tributaries and the increase in contribution from the upper Missouri River Basin in 2011 as compared to 1973 and the long-term average from 1950 to 2011.