In cooperation with the Missouri Department of Transportation, the U.S. Geological Survey determined hydrologic and hydraulic parameters for the Gasconade River at the site of a proposed bridge replacement and highway realignment of State Highway 17 near Waynesville, Missouri. Information from a discontinued streamflow-gaging station on the Gasconade River near Waynesville was used to determine streamflow statistics for analysis of the 25-, 50-, 100-, and 500-year floods at the site. Analysis of the streamflow-gaging stations on the Gasconade River upstream and downstream from Waynesville indicate that flood peaks attenuate between the upstream gaging station near Hazelgreen and the Waynesville gaging station, such that the peak discharge observed on the Gasconade River near Waynesville will be equal to or only slightly greater (7 percent or less) than that observed near Hazelgreen. A flood event occurred on the Gasconade River in March 2008, and a flood measurement was obtained near the peak at State Highway 17. The elevation of high-water marks from that event indicated it was the highest measured flood on record with a measured discharge of 95,400 cubic feet per second, and a water-surface elevation of 766.18 feet near the location of the Waynesville gaging station. The measurements obtained for the March flood resulted in a shift of the original stage-discharge relation for the Waynesville gaging station, and the streamflow statistics were modified based on the new data. A two-dimensional hydrodynamic flow model was used to simulate flow conditions on the Gasconade River in the vicinity of State Highway 17. A model was developed that represents existing (2008) conditions on State Highway 17 (the 'model of existing conditions'), and was calibrated to the floods of March 20, 2008, December 4, 1982, and April 14, 1945. Modifications were made to the model of existing conditions to create a model that represents conditions along the same reach of the Gasconade River with preliminary proposed replacement bridges and realignment of State Highway 17 (the 'model of proposed conditions'). The models of existing and proposed conditions were used to simulate the 25-, 50-, 100-, and 500-year recurrence floods, as well as the March 20, 2008 flood. Results from the model of proposed conditions show that the proposed replacement structures and realignment of State Highway 17 will result in additional backwater upstream from State Highway 17 ranging from approximately 0.18 foot for the 25-year flood to 0.32 foot for the 500-year flood. Velocity magnitudes in the proposed overflow structures were greater than in the existing structures [by as much as 4.9 feet per second in the left (west) overflow structure for the 500-year flood], and shallow, high-velocity flow occurs at the upstream edges of the abutments of the proposed overflow structures in the 100- and 500-year floods where flow overtops parts of the existing road embankment that will be left in place in the proposed scenario. Velocity magnitude in the main channel of the model of proposed conditions increased by a maximum of 1.2 feet per second over the model of existing conditions, with the maximum occurring approximately 1,500 feet downstream from existing main channel structure J-802.