Flow statistics can be used to provide decision makers with surface-water information needed for activities such as water-supply permitting, flow regulation, and other water rights issues. Flow statistics could be needed at any location along a stream. Most often, streamflow statistics are needed at ungaged sites, where no flow data are available to compute the statistics. Methods are presented in this report for estimating flow-duration and annual mean-flow statistics for ungaged streams in Oklahoma. Flow statistics included the (1) annual (period of record), (2) seasonal (summer-autumn and winter-spring), and (3) 12 monthly duration statistics, including the 20th, 50th, 80th, 90th, and 95th percentile flow exceedances, and the annual mean-flow (mean of daily flows for the period of record). Flow statistics were calculated from daily streamflow information collected from 235 streamflow-gaging stations throughout Oklahoma and areas in adjacent states. A drainage-area ratio method is the preferred method for estimating flow statistics at an ungaged location that is on a stream near a gage. The method generally is reliable only if the drainage-area ratio of the two sites is between 0.5 and 1.5. Regression equations that relate flow statistics to drainage-basin characteristics were developed for the purpose of estimating selected flow-duration and annual mean-flow statistics for ungaged streams that are not near gaging stations on the same stream. Regression equations were developed from flow statistics and drainage-basin characteristics for 113 unregulated gaging stations. Separate regression equations were developed by using U.S. Geological Survey streamflow-gaging stations in regions with similar drainage-basin characteristics. These equations can increase the accuracy of regression equations used for estimating flow-duration and annual mean-flow statistics at ungaged stream locations in Oklahoma. Streamflow-gaging stations were grouped by selected drainage-basin characteristics by using a k-means cluster analysis. Three regions were identified for Oklahoma on the basis of the clustering of gaging stations and a manual delineation of distinguishable hydrologic and geologic boundaries: Region 1 (western Oklahoma excluding the Oklahoma and Texas Panhandles), Region 2 (north- and south-central Oklahoma), and Region 3 (eastern and central Oklahoma). A total of 228 regression equations (225 flow-duration regressions and three annual mean-flow regressions) were developed using ordinary least-squares and left-censored (Tobit) multiple-regression techniques. These equations can be used to estimate 75 flow-duration statistics and annual mean-flow for ungaged streams in the three regions. Drainage-basin characteristics that were statistically significant independent variables in the regression analyses were (1) contributing drainage area; (2) station elevation; (3) mean drainage-basin elevation; (4) channel slope; (5) percentage of forested canopy; (6) mean drainage-basin hillslope; (7) soil permeability; and (8) mean annual, seasonal, and monthly precipitation. The accuracy of flow-duration regression equations generally decreased from high-flow exceedance (low-exceedance probability) to low-flow exceedance (high-exceedance probability) . This decrease may have happened because a greater uncertainty exists for low-flow estimates and low-flow is largely affected by localized geology that was not quantified by the drainage-basin characteristics selected. The standard errors of estimate of regression equations for Region 1 (western Oklahoma) were substantially larger than those standard errors for other regions, especially for low-flow exceedances. These errors may be a result of greater variability in low flow because of increased irrigation activities in this region. Regression equations may not be reliable for sites where the drainage-basin characteristics are outside the range of values of independent vari