The Leadville mining district is historically one of the most heavily mined regions in the world producing large quantities of gold, silver, lead, zinc, copper, and manganese since the 1860s. A multidisciplinary investigation was conducted by the U.S. Geological Survey, in cooperation with the Colorado Department of Public Health and Environment, to characterize large-scale groundwater flow in a 13 square-kilometer region encompassing the Canterbury Tunnel and the Leadville Mine Drainage Tunnel near Leadville, Colorado. The primary objective of the investigation was to evaluate whether a substantial hydraulic connection is present between the Canterbury Tunnel and Leadville Mine Drainage Tunnel for current (2008) hydrologic conditions. Altitude in the Leadville area ranges from about 3,018 m (9,900 ft) along the Arkansas River valley to about 4,270 m (14,000 ft) along the Continental Divide east of Leadville, and the high altitude of the area results in a moderate subpolar climate. Winter precipitation as snow was about three times greater than summer precipitation as rain, and in general, both winter and summer precipitation were greatest at higher altitudes. Winter and summer precipitation have increased since 2002 coinciding with the observed water-level rise near the Leadville Mine Drainage Tunnel that began in 2003. The weather patterns and hydrology exhibit strong seasonality with an annual cycle of cold winters with large snowfall, followed by spring snowmelt, runoff, and recharge (high-flow) conditions, and then base-flow (low-flow) conditions in the fall prior to the next winter. Groundwater occurs in the Paleozoic and Precambrian fractured-rock aquifers and in a Quaternary alluvial aquifer along the East Fork Arkansas River, and groundwater levels also exhibit seasonal, although delayed, patterns in response to the annual hydrologic cycle. A three-dimensional digital representation of the extensively faulted bedrock was developed and a geophysical direct-current resistivity field survey was performed to evaluate the geologic structure of the study area. The results show that the Canterbury Tunnel is located in a downthrown structural block that is not in direct physical connection with the Leadville Mine Drainage Tunnel. The presence of this structural discontinuity implies there is no direct groundwater pathway between the tunnels along a laterally continuous bedrock unit. Water-quality results for pH and major-ion concentrations near the Canterbury Tunnel showed that acid mine drainage has not affected groundwater quality. Stable-isotope ratios of hydrogen and oxygen in water indicate that snowmelt is the primary source of groundwater recharge. On the basis of chlorofluorocarbon and tritium concentrations and mixing ratios for groundwater samples, young groundwater (groundwater recharged after 1953) was indicated at well locations upgradient from and in a fault block separate from the Canterbury Tunnel. Samples from sites downgradient from the Canterbury Tunnel were mixtures of young and old (pre-1953) groundwater and likely represent snowmelt recharge mixed with older regional groundwater that discharges from the bedrock units to the Arkansas River valley. Discharge from the Canterbury Tunnel contained the greatest percentage of old (pre-1953) groundwater with a mixture of about 25 percent young water and about 75 percent old water. A calibrated three-dimensional groundwater model representing high-flow conditions was used to evaluate large-scale flow characteristics of the groundwater and to assess whether a substantial hydraulic connection was present between the Canterbury Tunnel and Leadville Mine Drainage Tunnel. As simulated, the faults restrict local flow in many areas, but the fracture-damage zones adjacent to the faults allow groundwater to move along faults. Water-budget results indicate that groundwater flow across the lateral edges of the model controlled the majority of flow in and out of the aquifer (79 percent and 63 percent of the total water budget, respectively). The largest contributions to the water budget were groundwater entering from the upper reaches of the watershed and the hydrologic interaction of the groundwater with the East Fork Arkansas River. Potentiometric surface maps of the simulated model results were generated for depths of 50, 100, and 250 m. The surfaces revealed a positive trend in hydraulic head with land-surface altitude and evidence of increased control on fluid movement by the fault network structure at progressively greater depths in the aquifer. Results of advective particle-tracking simulations indicate that the sets of simulated flow paths for the Canterbury Tunnel and the Leadville Mine Drainage Tunnel were mutually exclusive of one another, which also suggested that no major hydraulic connection was present between the tunnels. Particle-tracking simulations also revealed that although the fault network generally restricted groundwater movement locally, hydrologic conditions were such that groundwater did cross the fault network at many locations. This cross-fault movement indicates that the fault network controls regional groundwater flow to some degree but is not a complete barrier to flow. The cumulative distributions of adjusted age results for the watershed indicate that approximately 30 percent of the flow pathways transmit groundwater that was younger than 68 years old (post-1941) and that about 70 percent of the flow pathways transmit old groundwater. The particle-tracking results are consistent with the apparent ages and mixing ratios developed from the chlorofluorocarbon and tritium results. The model simulations also indicate that approximately 50 percent of the groundwater flowing through the study area was less than 200 years old and about 50 percent of the groundwater flowing through the study area is old water stored in low-permeability geologic units and fault blocks. As a final examination of model response, the conductance parameters of the Canterbury Tunnel and Leadville Mine Drainage Tunnel were manually adjusted from the calibrated values to determine if altering the flow discharge in one tunnel affects the hydraulic behavior in the other tunnel. The examination showed no substantial hydraulic connection. The multidisciplinary investigation yielded an improved understanding of groundwater characteristics near the Canterbury Tunnel and the Leadville Mine Drainage Tunnel. Movement of groundwater between the Canterbury Tunnel and Leadville Mine Drainage Tunnel that was central to this investigation could not be evaluated with strong certainty owing to the structural complexity of the region, study simplifications, and the absence of observation data within the upper sections of the Canterbury Tunnel and between the Canterbury Tunnel and the Leadville Mine Drainage Tunnel. There was, however, collaborative agreement between all of the analyses performed during this investigation that a substantial hydraulic connection did not exist between the Canterbury Tunnel and the Leadville Mine Drainage Tunnel under natural flow conditions near the time of this investigation.