Sedimentary rocks of Cambrian and Ordovician age form a major aquifer system in most of Wisconsin and Iowa, northern Illinois, northwestern Indiana, southeastern Minnesota, and northern Missouri. Many metropolitan areas depend on the aquifer for all or part of their water supplies. Declines in potentiometric head have been large in the most heavily pumped areas, most notably Chicago, Milwaukee-Waukesha, Minneapolis-St. Paul, and Des Moines. A thorough understanding of the aquifer system is needed for sound management decisions. Thus, a 4-year study of the aquifer, beginning in October 1978, is included in the U.S. Geological Survey 's program of Regional Aquifer-System Analysis. The study will evaluate the aquifer 's water-supply potential, describe its water quality, and, through computer models of the ground-water flow system, provide the means to evaluate regional aquifer response to different patterns of ground-water development. This report describes the objectives, work plan, and organization of this study. (Woodard-USGS)