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Mammalian sensitivity to elemental gold (Au?)

Biological Trace Element Research

6164_Eisler.pdf
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DOI: 10.1385/BTER:100:1:001

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Abstract

There is increasing documentation of allergic contact dermatitis and other effects from gold jewelry, gold dental restorations, and gold implants. These effects were especially pronounced among females wearing body-piercing gold objects. One estimate of the prevalence of gold allergy worldwide is 13%, as judged by patch tests with monovalent organogold salts. Eczema of the head and neck was the most common response of individuals hypersensitive to gold, and sensitivity can last for at least several years. Ingestion of beverages containing flake gold can result in allergic-type reactions similar to those seen in gold-allergic individuals exposed to gold through dermal contact and other routes. Studies with small laboratory mammals and injected doses of colloidal gold showed increased body temperatures, accumulations in reticular cells, and dose enhancement in tumor therapy; gold implants were associated with tissue injuries. It is proposed that Au? toxicity to mammals is associated, in part, with formation of the more reactive Au+ and Au3+ species.

Additional Publication Details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Mammalian sensitivity to elemental gold (Au?)
Series title:
Biological Trace Element Research
DOI:
10.1385/BTER:100:1:001
Volume
100
Issue:
1
Year Published:
2004
Language:
English
Publisher:
U.S. Fish and Wildlife Service
Contributing office(s):
Patuxent Wildlife Research Center
Description:
1-18
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Biological Trace Element Research
First page:
1
Last page:
18