Landscape development of central and northern Arizona can no longer be ascribed mainly to events of Miocene and Pliocene age. New information on the age and distribution of older Cenozoic deposits has led to the recognition of a regional Cretaceous-Paleocene(?) surface of erosion that conforms to major elements of the present topography and to the recognition that a formerly thick deposit of gravel accumulated on this regional surface of erosion. These relations cast new light on the history of evolution of the landscape and indicate a much greater age for the main landscape elements and a more complicated and prolonged history of erosion and deposition than has been previously supposed. The timing of events postulated for development of drainage on the Colorado Plateau can now be compared and partly reconciled with events recognized in the adjacent closely related Mountain Region (Transition Zone) of central Arizona. As a consequence of Late Cretaceous-Paleocene (Laramide) compression, central and northern Arizona underwent at least 1200 m of uplift, documented by paleochannels cut into erosionally truncated Paleozoic strata on the Hualapai Plateau of the southwestern Colorado Plateau. During this time, a highly irregular erosion surface was developed on Proterozoic rocks across the Transition Zone south of the Mogollon Rim, the scarp of the Mogollon Rim was eroded to its present height (600–900 m), and an extensive stripped surface was developed on resistant upper Paleozoic strata north of the rim. Deposition of several hundred meters of Paleocene-Eocene “Rim gravels” derived from highlands south and west of the region followed, covering much of the Cretaceous-Paleocene erosion surface. Nearly complete burial of the rim is suggested by the distribution of remnants of the Rim gravels across the erosional scarps and on high plateau areas north of the rim. A second increment of uplift, apparently occurring in late Eocene time and apparently recorded by a series of fission track cooling ages from the Marble and Grand canyons, is inferred to have been responsible for ending deposition of the Rim gravels, for initiating differential uplift of contemporaneous deposits (Canaan Peak and Claron formations) to their positions in the high plateaus of central Utah, and for causing the drainage reorganization required to explain the extensive removal of Rim gravels from much of the region. A southerly flowing ancestral Verde River related to the drainage reorganization removed much of the older gravel cover from the Transition Zone of central Arizona, resulting in a younger regional erosion surface having 600–900 m of relief, a surface closely approximating the Cretaceous-Paleocene erosion surface. Late Oligocene and early Miocene rocks locally rest unconformably on remnants of Rim gravels in the Transition Zone, indicating that the second episode of regional erosion had been completed by late Oligocene time. North of the Mogollon Rim, a west flowing(?) ancestral Colorado River is inferred to have become established on the Rim gravels, draining the interior parts of the Colorado Plateau and transporting detritus off the plateau. Exhumation of the Mogollon Rim and development of 600–900 m of topographic relief in the Transition Zone by an ancestral Verde River system suggests the potential for a comparable, coeval entrenchment of an ancestral Colorado River in Paleozoic strata north of the Mogollon Rim. Regional extension and volcanic activity ensued in late Oligocene to Pliocene time. The Oligocene erosion surface in the extensional basins of central Arizona became largely concealed by Miocene and Pliocene deposits as the Neogene climate became drier. In late Miocene and Pliocene time, perennial streams appear to have been lacking, transport of detritus appears to have been principally by flash flooding, little or no detritus appears to have been removed from the region, and much of the precipitation presumably moved by groundwater flow through the deposits of aggradation. A coeval episode of aggradation in the Grand Canyon is suggested by deposits that appear to have once choked much of the canyon. If this event parallels the episode of late Miocene and Pliocene aggradation recorded east, south, and west of the Grand Canyon, the Colorado River could have been incised to its present level by late Miocene time. A return to wetter conditions in late Pliocene time presumably was responsible for renewed erosion and reexcavation of older drainages and basins. An understanding of this Tertiary structural, erosional, and depositional history can be important for the geological analysis of geophysical transects across the region.