Turnover and urinary excretion of free and acetylated MS-222 rainbow trout, Salmo gairdneri

Journal of the Fisheries Research Board of Canada
By: , and 

Links

Abstract

Rainbow trout (Salmo gairdneri) anesthetized in 100 mg/liter of M.S. 222 at 12 C excreted the drug in free and acetylated forms via the urine during a 24-hr recovery period in freshwater. Of the M.S. 222 excreted, 77-96% was acetylated. Blood levels of free drug in anesthetized trout approximated 75% of the anesthetic concentration, but the amount of acetylated M.S. 222 was relatively insignificant. The blood and urine were cleared of the two fractions of M.S. 222 in 8 and 24 hr respectively. Low levels of aromatic amines of natural origin occurred in blood and urine and were subtracted from measurements of M.S. 222. Intraperitoneal injections of 10-100 mg/kg of M.S. 222 did not induce anesthesia; however, the 24-hr pattern of drug excretion was similar to that observed after anesthesia by immersion. Only 15-21 % of the injected dose was found in the urine, suggesting a second route of drug elimination.

Additional publication details

Publication type Article
Publication Subtype Journal Article
Title Turnover and urinary excretion of free and acetylated MS-222 rainbow trout, Salmo gairdneri
Series title Journal of the Fisheries Research Board of Canada
DOI 10.1139/f68-003
Volume 25
Issue 1
Year Published 1968
Language English
Contributing office(s) Upper Midwest Environmental Sciences Center
Description pp. 25-31
Larger Work Type Article
Larger Work Subtype Journal Article
Larger Work Title Journal of the Fisheries Research Board of Canada
First page 25
Last page 31
Google Analytic Metrics Metrics page
Additional metadata about this publication, not found in other parts of the page is in this table