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Possible mechanisms for sensitivity to organophosphorus and carbamate insecticides in eastern screech-owls and American kestrels

Comparative Biochemistry and Physiology, Part C: Pharmacology, Toxicology and Endocrinology

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, , and
https://doi.org/10.1016/S0742-8413(98)00036-X

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Abstract

Effects of a single dietary exposure to fenthion and carbofuran on the survival, feeding behavior and brain ChE activity of eastern screech-owls, Otus asio and American kestrels, Falco sparverius, were evaluated. Birds were exposed to fenthion (23.6–189.0 ppm) or carbofuran (31.7–253.6 ppm) via meatballs. Carbofuran-exposed owls ate either ≤10% or ≥80% of the meatball whereas all kestrels ate ≤10% of the meatball before exhibiting acute signs of toxicity. Fenthion-exposed owls and kestrels displayed a wide spectrum of meatball consumption (<10–100%). Significant brain ChE inhibition was observed in dead and surviving kestrels exposed to fenthion and carbofuran and dead owls exposed to fenthion (P<0.0001). Brain ChE activity of owls exposed to carbofuran that survived was not different from that of controls (P=0.25). Data suggest: (1) slow feeding on a carbamate-contaminated item may provide limited protection from the toxicity of the chemical at certain rates of exposure; (2) the degree of ChE inhibition at neuromuscular junctions may be critical in determining the sensitivity of a species to a carbamate insecticide; (3) sensitivity may be a function of the ChE affinity for the carbamate inhibitor; and (4) the importance of neuromuscular junction ChE depression in determining the sensitivity of an animal may be species-specific.

Additional publication details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Possible mechanisms for sensitivity to organophosphorus and carbamate insecticides in eastern screech-owls and American kestrels
Series title:
Comparative Biochemistry and Physiology, Part C: Pharmacology, Toxicology and Endocrinology
DOI:
10.1016/S0742-8413(98)00036-X
Volume:
120
Issue:
1
Year Published:
1998
Language:
English
Publisher:
Elsevier
Contributing office(s):
Patuxent Wildlife Research Center
Description:
7 p.
First page:
151
Last page:
157