Most of the great California-Nevada heat waves can be classified into primarily daytime or nighttime events depending on whether atmospheric conditions are dry or humid. A rash of nighttime-accentuated events in the last decade was punctuated by an unusually intense case in July 2006, which was the largest heat wave on record (1948-2006). Generally, there is a positive trend in heat wave activity over the entire region that is expressed most strongly and clearly in nighttime rather than daytime temperature extremes. This trend in nighttime heat wave activity has intensified markedly since the 1980s and especially since 2000. The two most recent nighttime heat waves were also strongly expressed in extreme daytime temperatures. Circulations associated with great regional heat waves advect hot air into the region. This air can be dry or moist, depending on whether a moisture source is available, causing heat waves to be expressed preferentially during day or night. A remote moisture source centered within a marine region west of Baja California has been increasing in prominence because of gradual sea surface warming and a related increase in atmospheric humidity. Adding to the very strong synoptic dynamics during the 2006 heat wave were a prolonged stream of moisture from this southwestern source and, despite the heightened humidity, an environment in which afternoon convection was suppressed, keeping cloudiness low and daytime temperatures high. The relative contributions of these factors and possible relations to global warming are discussed. ?? 2009 American Meteorological Society.