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Soil clay content underlies prion infection odds

Nature Communications

By:
, , , , and
https://doi.org/10.1038/ncomms1203

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Abstract

Environmental factors-especially soil properties-have been suggested as potentially important in the transmission of infectious prion diseases. Because binding to montmorillonite (an aluminosilicate clay mineral) or clay-enriched soils had been shown to enhance experimental prion transmissibility, we hypothesized that prion transmission among mule deer might also be enhanced in ranges with relatively high soil clay content. In this study, we report apparent influences of soil clay content on the odds of prion infection in free-ranging deer. Analysis of data from prion-infected deer herds in northern Colorado, USA, revealed that a 1% increase in the clay-sized particle content in soils within the approximate home range of an individual deer increased its odds of infection by up to 8.9%. Our findings suggest that soil clay content and related environmental properties deserve greater attention in assessing risks of prion disease outbreaks and prospects for their control in both natural and production settings. ?? 2011 Macmillan Publishers Limited. All rights reserved.

Additional publication details

Publication type:
Article
Publication Subtype:
Journal Article
Title:
Soil clay content underlies prion infection odds
Series title:
Nature Communications
DOI:
10.1038/ncomms1203
Volume:
2
Issue:
1
Year Published:
2011
Language:
English
Contributing office(s):
National Wildlife Health Center
Larger Work Type:
Article
Larger Work Subtype:
Journal Article
Larger Work Title:
Nature Communications